Current Issue 21 May 2012, Vol. 586, No. 10

Issue Highlights

Focus on... Ubiquitin-Related Tumor Suppressors

Mdm2 and MdmX partner to regulate p53
21 May 2012(Vol. 586 | No. 10 | Pages 1390-1396)
Xinjiang Wang, Xuejun Jiang
- Abstract
- Full Text on ScienceDirect

Pirh2 RING-finger E3 ubiquitin ligase: Its role in tumorigenesis and cancer therapy
21 May 2012(Vol. 586 | No. 10 | Pages 1397-1402)
Yong-Sam Jung, Yingjuan Qian, Xinbin Chen
- Abstract
- Full Text on ScienceDirect

Merlin, a multi-suppressor from cell membrane to the nucleus
21 May 2012(Vol. 586 | No. 10 | Pages 1403-1408)
Lu Zhou, C. Oliver Hanemann
- Abstract
- Full Text on ScienceDirect

PHD finger of the SUMO ligase Siz/PIAS family in rice reveals specific binding for methylated histone H3 at lysine 4 and arginine 2
22 May 2012
Heisaburo Shindo, Rintaro Suzuki, Wataru Tsuchiya, Misako Taichi, Yuji Nishiuchi, Toshimasa Yamazaki
Highlights: ► We determined the structure of PHD in a rice SUMO ligase Siz1 (OsSiz1–PHD) by NMR. ► OsSiz1–PHD primarily recognizes dimethylated Arg2 of histone H3. ► Methylations at Arg2 and Lys4 of H...
The human phosphatase interactome: an intricate family portrait
22 May 2012
Francesca Sacco, Livia Perfetto, Luisa Castagnoli, Gianni Cesareni
Abstract: The concerted activities of kinases and phosphatases modulate the phosphorylation levels of proteins, lipids and carbohydrates in eukaryotic cells. Despite considerable effort, we are still ...
Abi1, a critical molecule coordinating actin cytoskeleton reorganization with PI-3 kinase and growth signaling
21 May 2012
Leszek Kotula
Abstract: Coordination of actin cytoskeletal reorganization with growth and proliferation signals is a key cellular process that is not fully understood. PI-3 kinase is one of the central nodes for di...
Redesigning the single-chain variant of the restriction endonuclease PvuII by circular permutation
21 May 2012
Benno Schierling, Wolfgang Wende, Alfred Pingoud
Highlights: ► The single-chain variant of PvuII was structurally redesigned by circular permutation. ► DNA recognition and catalysis of the permuted variants of scPvuII were characterized. ► The permu...
A plant microRNA regulates the adaptation of roots to drought stress
21 May 2012
Hao Chen, Zhuofu Li, Liming Xiong
Highlights: ► The Arabidopsis mutant fry1 is sensitive to ABA in the inhibition of lateral root growth and has a higher level of miR393. ► ABA decreases the expression of the wild-type but not miR393-...

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