Current Issue 3 February 2012, Vol. 586, No. 3

Issue Highlights

Research Letters with SDA

C-terminal residues of Oryza sativa GUN4 are required for the activation of the ChlH subunit of magnesium chelatase in chlorophyll synthesis
3 February 2012(Vol. 586 | No. 3 | Pages 205-210)
Shuaixiang Zhou, Artur Sawicki, Robert D. Willows, Meizhong Luo

FLU, a negative feedback regulator of tetrapyrrole biosynthesis, is physically linked to the final steps of the Mg++-branch of this pathway
3 February 2012(Vol. 586 | No. 3 | Pages 211-216)
Dominika Kauss, Sylvain Bischof, Sandro Steiner, Klaus Apel, Rasa Meskauskiene

Activation of macrophage-stimulating protein by human airway trypsin-like protease
3 February 2012(Vol. 586 | No. 3 | Pages 217-221)
Hiroshi Orikawa, Makiko Kawaguchi, Takashi Baba, Kenji Yorita, Sumio Sakoda, Hiroaki Kataoka

Overexpression of lalA, a paralog of labA, is capable of affecting both circadian gene expression and cell growth in the cyanobacterium Synechococcus elongatus PCC 7942
27 January 2012
Yasuhito Taniguchi, Tomoe Nishikawa, Takao Kondo, Tokitaka Oyama
Highlights: ► lalA is a paralog of the cyanobacterial clock-related gene labA. ► lalA overexpression reduced amplitude of circadian kaiBC expression. ► lalA overexpression advanced phases of circadian...
Cyclin-dependent kinase 4 is a novel target in micoRNA-195-mediated cell cycle arrest in bladder cancer cells
27 January 2012
Yiwei Lin, Jian Wu, Hong Chen, Yeqing Mao, Yunfu Liu, Qiqi Mao, Kai Yang, Xiangyi Zheng, Liping Xie
Highlight: ► miR-195 is down-regulated in bladder cancer tissue samples. ► miR-195 inhibits bladder cancer cell T24 growth both in vitro and in vivo. ► miR-195 could induce T24 cell cycle arrest by su...
LY294002 inhibits TLR3/4-mediated IFN-β production via inhibition of IRF3 activation with a PI3K-independent mechanism
27 January 2012
Wei Zhao, Jianni Qi, Lijuan Wang, Meng Zhang, Peng Wang, Chengjiang Gao
Highlights: ► LY294002 and wortmannin have opposite functions on LPS- and poly(I:C)-induced IFN-β production. ► LY294002 inhibits LPS- and poly(I:C)-induced IFN-β transcription and secretion in a PI3K...
Phosphate homeostasis in the yeast Saccharomyces cerevisiae, the key role of the SPX domain-containing proteins
27 January 2012
David Secco, Chuang Wang, Huixia Shou, James Whelan
Abstract: In the yeast Saccharomyces cerevisiae, a working model for nutrient homeostasis in eukaryotes, inorganic phosphate (Pi) homeostasis is regulated by the PHO pathway, a set of phosphate starva...
Novel assay with fluorescence-labeled PrP peptides for differentiating L-type atypical and classical BSEs, and scrapie
27 January 2012
Kazuo Kasai, Akiyoshi Hitara, Takafumi Ohyama, Kiyoshi Nokihara, Takashi Yokoyama, Shirou Mohri
Abstract Characteristic differences of prions may account for the conformational diversity of the pathogenic isoform of prion protein (PrPSc). Here, we applied a protein detection procedure by using f...

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