Hypothesis

 

2011

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Article Title Author(s) Type Pages
Are there errors in glycogen biosynthesis and is laforin a repair enzyme?

20 October 2011 (Vol. 585 | No. 20 | Pages 3216-3218)

Peter J. Roach Short communication

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3216-3218
The beta-isoform of neuronal nitric oxide synthase (nNOS) lacking the PDZ domain is localized at the sarcolemma

20 October 2011 (Vol. 585 | No. 20 | Pages 3219-3223)

Oliver Baum, Simon Schläppi, Felicitas A. Huber-Abel, Alexander Weichert, Hans Hoppeler, Andreas Zakrzewicz et al. Short communication

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3219-3223
Denatured bactericidal proteins: Active per se, or reservoirs of active peptides?

4 August 2011 (Vol. 585 | No. 15 | Pages 2403-2404)

Giuseppe D’Alessio Short communication

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2403-2404
Unravelling the different functions of protein kinase C isoforms in platelets

23 June 2011 (Vol. 585 | No. 12 | Pages 1711-1716)

Johan W.M. Heemskerk, Matthew T. Harper, Judith M.E.M. Cosemans, Alastair W. Poole Short communication

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1711-1716
A mechanism for regulation of chloroplast LHC II kinase by plastoquinol and thioredoxin

23 June 2011 (Vol. 585 | No. 12 | Pages 1717-1721)

Sujith Puthiyaveetil Short communication

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1717-1721
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2010

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AmtB-mediated NH3 transport in prokaryotes must be active and as a consequence regulation of transport by GlnK is mandatory to limit futile cycling of

3 January 2011 (Vol. 585 | No. 1 | Pages 23-28)

Fred C. Boogerd, Hongwu Ma, Frank J. Bruggeman, Wally C. van Heeswijk, Rodolfo García-Contreras, Douwe Molenaar, Klaas Krab, Hans V. Westerhoff et al. Short communication

23-28
A conserved gene cluster as a putative functional unit in insect innate immunity

5 November 2010 (Vol. 584 | No. 21 | Pages 4375-4378)

Kálmán Somogyi, Botond Sipos, Zsolt Pénzes, István Andó Short communication

4375-4378
DYW-type PPR proteins in a heterolobosean protist: Plant RNA editing factors involved in an ancient horizontal gene transfer?

22 October 2010 (Vol. 584 | No. 20 | Pages 4287-4291)

Volker Knoop, Mareike Rüdinger Short communication

4287-4291
A new hypothesis on the simultaneous direct and indirect proton pump mechanisms in NADH-quinone oxidoreductase (complex I)

8 October 2010 (Vol. 584 | No. 19 | Pages 4131-4137)

Tomoko Ohnishi, Eiko Nakamaru-Ogiso, S. Tsuyoshi Ohnishi Short communication

4131-4137
A model for signaling specificity of Wnt/Frizzled combinations through co-receptor recruitment

24 September 2010 (Vol. 584 | No. 18 | Pages 3850-3854)

Folkert Verkaar, Guido J.R. Zaman Short communication

3850-3854
Nucleosome deposition and DNA methylation may participate in the recognition of premature termination codon in nonsense-mediated mRNA decay

20 August 2010 (Vol. 584 | No. 16 | Pages 3509-3512)

Deng-Ke Niu, Jian-Li Cao Short communication

3509-3512
Glucose transporter 10 and arterial tortuosity syndrome: The vitamin C connection

16 July 2010 (Vol. 584 | No. 14 | Pages 2990-2994)

Fernando Segade Short communication

2990-2994
Oxidative folding in the endoplasmic reticulum: Towards a multiple oxidant hypothesis?

16 July 2010 (Vol. 584 | No. 14 | Pages 2995-2998)

Éva Margittai, Gábor Bánhegyi Short communication

2995-2998
On the role of the chaperonin CCT in the just-in-time assembly process of APC/CCdc20

5 February 2010 (Vol. 584 | No. 3 | Pages 477-481)

Carien Dekker Short communication

477-481
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2009

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Article Title Author(s) Type Pages
Activation of antithrombin as a factor IXa and Xa inhibitor involves mitigation of repression rather than positive enhancement

3 November 2009 (Vol. 583 | No. 21 | Pages 3397-3400)

Peter G.W. Gettins, Steven T. Olson Short communication

3397-3400
The direction of actin polymerization for vesicle fission suggested from membranes tubulated by the EFC/F-BAR domain protein FBP17

3 November 2009 (Vol. 583 | No. 21 | Pages 3401-3404)

Shiro Suetsugu Short communication

3401-3404
Cardiolipin-enriched raft-like microdomains are essential activating platforms for apoptotic signals on mitochondria

6 August 2009 (Vol. 583 | No. 15 | Pages 2447-2450)

Maurizio Sorice, Valeria Manganelli, Paola Matarrese, Antonella Tinari, Roberta Misasi, Walter Malorni, Tina Garofalo et al. Short communication

2447-2450
Electric dipole reorientation in the interaction of botulinum neurotoxins with neuronal membranes

21 July 2009 (Vol. 583 | No. 14 | Pages 2321-2325)

Federico Fogolari, Silvio C.E. Tosatto, Lucia Muraro, Cesare Montecucco Short communication

2321-2325
Are the effects of α-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract?

7 July 2009 (Vol. 583 | No. 13 | Pages 2157-2159)

Yoshihiko Suzuki, Motoaki Sano, Kentaro Hayashida, Ikuroh Ohsawa, Shigeo Ohta, Keiichi Fukuda et al. Short communication

2157-2159
Does distant homology with Evf reveal a lipid binding site in Bacillus thuringiensis cytolytic toxins?

19 May 2009 (Vol. 583 | No. 10 | Pages 1555-1560)

Daniel J. Rigden Short communication

1555-1560
Telomere heterogeneity: Taking advantage of stochastic events

2 April 2009 (Vol. 583 | No. 7 | Pages 1067-1071)

Lubomir Tomaska, Jozef Nosek Short communication

1067-1071
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2008

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Distinctive biochemistry in the trypanosome mitochondrial intermembrane space suggests a model for stepwise evolution of the MIA pathway for import of cysteine-rich proteins

20 August 2008 (Vol. 582 | No. 19 | Pages 2817-2825)

James W.A. Allen, Stuart J. Ferguson, Michael L. Ginger Short communication

2817-2825
Neuronal nitric oxide synthase: Prototype for pulsed enzymology

30 April 2008 (Vol. 582 | No. 10 | Pages 1395-1399)

John C. Salerno Short communication

1395-1399
uORFs, reinitiation and alternative translation start sites in human mRNAs

16 April 2008 (Vol. 582 | No. 9 | Pages 1293-1297)

Alex V. Kochetov, Shandar Ahmad, Vladimir Ivanisenko, Oxana A. Volkova, Nikolay A. Kolchanov, Akinori Sarai et al. Short communication

1293-1297
New uses for old drugs. Auranofin, a clinically established antiarthritic metallodrug, exhibits potent antimalarial effects in vitro: Mechanistic and pharmacological implications

19 March 2008 (Vol. 582 | No. 6 | Pages 844-847)

Anna Rosa Sannella, Angela Casini, Chiara Gabbiani, Luigi Messori, Anna Rita Bilia, Francesco Franco Vincieri, Giancarlo Majori, Carlo Severini et al. Short communication

844-847
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2007

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Differential colchicine-binding across eukaryotic families: The role of highly conserved Pro268β and Ala248β residues in animal tubulin

30 October 2007 (Vol. 581 | No. 26 | Pages 5019-5023)

Mithu Banerjee, Debjani Roy, B. Bhattacharyya, Gautam Basu Short communication

5019-5023
A hypothesis on the identification of the editing enzyme in plant organelles

4 September 2007 (Vol. 581 | No. 22 | Pages 4132-4138)

Véronique Salone, Mareike Rüdinger, Monika Polsakiewicz, Beate Hoffmann, Milena Groth-Malonek, Boris Szurek, Ian Small, Volker Knoop, Claire Lurin et al. Short communication

4132-4138
Do mitochondria act as “cargo boats” in the journey of GD3 to the nucleus during apoptosis?

21 August 2007 (Vol. 581 | No. 21 | Pages 3899-3903)

Tina Garofalo, Antonella Tinari, Paola Matarrese, Anna Maria Giammarioli, Valeria Manganelli, Laura Ciarlo, Roberta Misasi, Maurizio Sorice, Walter Malorni et al. Short communication

3899-3903
Hypothesis on chlorosome biogenesis in green photosynthetic bacteria

6 March 2007 (Vol. 581 | No. 5 | Pages 800-803)

Martin F. Hohmann-Marriott, Robert E. Blankenship Short communication

800-803
Intermonomer electron transfer in the bc1 complex dimer is controlled by the energized state and by impaired electron transfer between low and high potential hemes

17 April 2007 (Vol. 581 | No. 8 | Pages 1535-1541)

Vladimir P. Shinkarev, Colin A. Wraight Short communication

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1535-1541
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2006

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The constant variation: DNA methylation changes during preimplantation development

11 December 2006 (Vol. 580 | No. 28 | Pages 6521-6526)

Tamás Arányi, András Páldi Short communication

6521-6526
Atomic determinants of state-dependent block of sodium channels by charged local anesthetics and benzocaine

13 November 2006 (Vol. 580 | No. 26 | Pages 6027-6032)

Denis B. Tikhonov, Iva Bruhova, Boris S. Zhorov Short communication

6027-6032
A model for co-translational translocation: Ribosome-regulated nascent polypeptide translocation at the protein-conducting channel

12 June 2006 (Vol. 580 | No. 14 | Pages 3353-3360)

Kakoli Mitra, Joachim Frank Short communication

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3353-3360
Ubiquinone (coenzyme Q10) binding sites: Low dielectric constant of the gate prevents the escape of the semiquinone

15 May 2006 (Vol. 580 | No. 11 | Pages 2534-2539)

V.P. Shinkarev Short communication

2534-2539
Cytochrome c6A is a funnel for thiol oxidation in the thylakoid lumen

17 April 2006 (Vol. 580 | No. 9 | Pages 2166-2169)

Beatrix G. Schlarb-Ridley, Robert H. Nimmo, Saul Purton, Christopher J. Howe, Derek S. Bendall et al. Short communication

2166-2169
The catalytic power of enzymes: Conformational selection or transition state stabilization?

17 April 2006 (Vol. 580 | No. 9 | Pages 2170-2177)

Jesús Giraldo, David Roche, Xavier Rovira, Juan Serra Short communication

2170-2177
Does the proteome encode organellar pH?

6 February 2006 (Vol. 580 | No. 3 | Pages 717-719)

Christopher L. Brett, Mark Donowitz, Rajini Rao Short communication

717-719
Salting-in the microbial cytoplasm

6 February 2006 (Vol. 580 | No. 3 | Pages 720-722)

F.N. Braun Short communication

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720-722
A radical solution for the biosynthesis of the H-cluster of hydrogenase

23 January 2006 (Vol. 580 | No. 2 | Pages 363-367)

John W. Peters, Robert K. Szilagyi, Anatoli Naumov, Trevor Douglas Short communication

363-367
A physical model for the condensation and decondensation of eukaryotic chromosomes

23 January 2006 (Vol. 580 | No. 2 | Pages 368-372)

Julien Mozziconacci, Christophe Lavelle, Maria Barbi, Annick Lesne, Jean-Marc Victor et al. Short communication

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368-372
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2005

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Endotoxin recognition: In fish or not in fish?

5 December 2005 (Vol. 579 | No. 29 | Pages 6519-6528)

Dimitar B. Iliev, Jared C. Roach, Simon Mackenzie, Josep V. Planas, Frederick W. Goetz et al. Short communication

6519-6528
Regulation of the F0F1-ATP synthase: The conformation of subunit ε might be determined by directionality of subunit γ rotation

26 September 2005 (Vol. 579 | No. 23 | Pages 5114-5118)

Boris A. Feniouk, Wolfgang Junge Short communication

5114-5118
A possible flip-flop genetic mechanism for reciprocal gene expression

12 September 2005 (Vol. 579 | No. 22 | Pages 4919-4922)

Maria Luisa Chiusano, Rossella Di Giaimo, Nicoletta Potenza, Giuseppina M.R. Russo, Giuseppe Geraci, Rosanna del Gaudio et al. Short communication

4919-4922
Conformation-driven and semiquinone-gated proton-pump mechanism in the NADH-ubiquinone oxidoreductase (complex I)

29 August 2005 (Vol. 579 | No. 21 | Pages 4555-4561)

Tomoko Ohnishi, John C. Salerno Short communication

4555-4561
Control of the light harvesting function of chloroplast membranes: The LHCII-aggregation model for non-photochemical quenching

15 August 2005 (Vol. 579 | No. 20 | Pages 4201-4206)

Peter Horton, Mark Wentworth, Alexander Ruban Short communication

4201-4206
Sodium channel activators: Model of binding inside the pore and a possible mechanism of action

15 August 2005 (Vol. 579 | No. 20 | Pages 4207-4212)

Denis B. Tikhonov, Boris S. Zhorov Short communication

4207-4212
Occurrence of the aminoacyl-tRNA synthetases in high-molecular weight complexes correlates with the size of substrate amino acids

4 July 2005 (Vol. 579 | No. 17 | Pages 3467-3472)

Alexey Wolfson, Rob Knight Short communication

3467-3472
Water and molecular chaperones act as weak links of protein folding networks: Energy landscape and punctuated equilibrium changes point towards a game theory of proteins

25 April 2005 (Vol. 579 | No. 11 | Pages 2254-2260)

István A. Kovács, Máté S. Szalay, Peter Csermely Short communication

2254-2260
Molecular mimicry may contribute to pathogenesis of ulcerative colitis

25 April 2005 (Vol. 579 | No. 11 | Pages 2261-2266)

Gopala Kovvali, Kiron M. Das Short communication

2261-2266
RNA silencing: A remarkable parallel to protein-based immune systems in vertebrates?

25 April 2005 (Vol. 579 | No. 11 | Pages 2267-2272)

Weizao Chen, Mingqiu Liu, Gong Cheng, Weiyao Yan, Liang Fei, Zhaoxin Zheng et al. Short communication

2267-2272
Simulating redox coupled proton transfer in cytochrome c oxidase: Looking for the proton bottleneck

11 April 2005 (Vol. 579 | No. 10 | Pages 2026-2034)

Mats H.M. Olsson, Pankaz K. Sharma, Arieh Warshel Short communication

2026-2034
Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity

11 April 2005 (Vol. 579 | No. 10 | Pages 2035-2039)

Massimo De Martinis, Claudio Franceschi, Daniela Monti, Lia Ginaldi Short communication

2035-2039
Are splicing mutations the most frequent cause of hereditary disease?

28 March 2005 (Vol. 579 | No. 9 | Pages 1900-1903)

Núria López-Bigas, Benjamin Audit, Christos Ouzounis, Genís Parra, Roderic Guigó et al. Short communication

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1900-1903
Robustness, evolvability, and neutrality

21 March 2005 (Vol. 579 | No. 8 | Pages 1772-1778)

Andreas Wagner Short communication

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1772-1778
Robustness, evolvability, and neutrality

21 March 2005 (Vol. 579 | No. 8 | Pages 1772-1778)

Andreas Wagner Short communication

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1772-1778
GC–MS libraries for the rapid identification of metabolites in complex biological samples

28 February 2005 (Vol. 579 | No. 6 | Pages 1332-1337)

Nicolas Schauer, Dirk Steinhauser, Sergej Strelkov, Dietmar Schomburg, Gordon Allison, Thomas Moritz, Krister Lundgren, Ute Roessner-Tunali, Megan G. Forbes, Lothar Willmitzer, Alisdair R. Fernie, Joachim Kopka et al. Short communication

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1332-1337
A redox switch hypothesis for the origin of two light reactions in photosynthesis

14 February 2005 (Vol. 579 | No. 5 | Pages 963-968)

John F. Allen Short communication

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963-968
Mimotope-hormesis and mortalin/grp75/mthsp70: a new hypothesis on how infectious disease-associated epitope mimicry may explain low cancer burden in developing nations

31 January 2005 (Vol. 579 | No. 3 | Pages 586-590)

Custer C. Deocaris, Kazunari Taira, Sunil C. Kaul, Renu Wadhwa Short communication

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586-590
Combining data from genomes, Y2H and 3D structure indicates that BolA is a reductase interacting with a glutaredoxin

31 January 2005 (Vol. 579 | No. 3 | Pages 591-596)

Martijn A. Huynen, Chris A.E.M. Spronk, Toni Gabaldón, Berend Snel Short communication

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591-596
Stochastic variation in the concentration of a repressor activates GAL genetic switch: implications in evolution of regulatory network

31 January 2005 (Vol. 579 | No. 3 | Pages 597-603)

Paike Jayadeva Bhat, K.V. Venkatesh Short communication

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597-603

2004

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A model of a transmembrane drug-efflux pump from Gram-negative bacteria

3 December 2004 (Vol. 578 | No. 1 | Pages 5-9)

Juan Fernandez-Recio, Fabien Walas, Luca Federici, J. Venkatesh Pratap, Vassiliy N. Bavro, Ricardo Nunez Miguel, Kenji Mizuguchi, Ben Luisi et al. Short communication

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5-9
Rendezvous in a membrane: close packing, hydrogen bonding, and the formation of transmembrane helix oligomers

5 November 2004 (Vol. 577 | No. 1 | Pages 5-8)

Dirk Schneider Short communication

5-8
The evolution of A-, F-, and V-type ATP synthases and ATPases: reversals in function and changes in the H+/ATP coupling ratio

8 October 2004 (Vol. 576 | No. 1 | Pages 1-4)

Richard L. Cross, Volker Müller Short communication

1-4
HLA-B27 lacking associated β2-microglobulin rearranges to auto-display or cross-display residues 169–181: a novel molecular mechanism for spondyloarthropathies

24 September 2004 (Vol. 575 | No. 1 | Pages 1-8)

Manni Luthra-Guptasarma, Balvinder Singh Short communication

1-8
Coupling between vesicle shape and the non-homogeneous lateral distribution of membrane constituents in Golgi bodies

10 September 2004 (Vol. 574 | No. 1 | Pages 9-12)

Aleš Iglič, Miha Fošnarič, Henry Hägerstrand, Veronika Kralj-Iglič Short communication

9-12
The unprecedented nos gene cluster of Wolinella succinogenes encodes a novel respiratory electron transfer pathway to cytochrome c nitrous oxide reductase

2 July 2004 (Vol. 569 | No. 1 | Pages 7-12)

Jörg Simon, Oliver Einsle, Peter M.H Kroneck, Walter G Zumft Short communication

7-12
Biotic and heavy metal stress response in plants: evidence for common signals

21 May 2004 (Vol. 566 | No. 1 | Pages 1-5)

Axel Mithöfer, Birgit Schulze, Wilhelm Boland Short communication

1-5
MDMA (Ecstasy) controls in concert a group of genes involved in GABA neurotransmission

9 April 2004 (Vol. 563 | No. 1 | Pages 3-6)

Rabi Simantov, Weiping Peng Full-length article

3-6
Resolving the evolutionary paradox of genetic instability: a cost–benefit analysis of DNA repair in changing environments

9 April 2004 (Vol. 563 | No. 1 | Pages 7-12)

Jarle Breivik, Gustav Gaudernack Full-length article

7-12
A hypothesis to explain division site selection in Escherichia coli by combining nucleoid occlusion and Min

12 March 2004 (Vol. 561 | No. 1 | Pages 3-10)

Vic Norris, Conrad Woldringh, Eugenia Mileykovskaya Full-length article

3-10
Animal deoxyribonucleoside kinases: ‘forward’ and ‘retrograde’ evolution of their substrate specificity1

27 February 2004 (Vol. 560 | No. 1 | Pages 3-6)

Jure Piškur, Michael P.B Sandrini, Wolfgang Knecht, Birgitte Munch-Petersen Full-length article

3-6
Agonist induction, conformational selection, and mutant receptors

2 January 2004 (Vol. 556 | No. 1 | Pages 13-18)

Jesús Giraldo Full-length article

13-18
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2003

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Simultaneous activation of apoptosis and inflammation in pathogenesis of septic shock: a hypothesis1

4 December 2003 (Vol. 555 | No. 2 | Pages 180-184)

Vishwas D Joshi, Dhananjaya V Kalvakolanu, Alan S Cross Full-length article

180-184
Sub-classification of response regulators using the surface characteristics of their receiver domains

20 November 2003 (Vol. 554 | No. 3 | Pages 231-236)

Douglas J Kojetin, Richele J Thompson, John Cavanagh Full-length article

231-236
Are non-functional, unfolded proteins (‘junk proteins’) common in the genome?

20 November 2003 (Vol. 554 | No. 3 | Pages 237-239)

Simon C Lovell Full-length article

237-239
In search of the prototype of nitric oxide synthase

6 November 2003 (Vol. 554 | No. 1 | Pages 1-5)

Tomasz Zemojtel, Rebecca C Wade, Thomas Dandekar Full-length article

1-5
Why do mammalian mitochondria possess a mismatch repair activity?

6 November 2003 (Vol. 554 | No. 1 | Pages 6-9)

P.A. Mason, R.N. Lightowlers Full-length article

6-9
Differential interaction of the two cholesterol-dependent, membrane-damaging toxins, streptolysin O and Vibrio cholerae cytolysin, with enantiomeric cholesterol

23 October 2003 (Vol. 553 | No. 3 | Pages 229-231)

Alexander Zitzer, Emily J Westover, Douglas F Covey, Michael Palmer Full-length article

229-231
Catalysis, evolution and life

9 October 2003 (Vol. 553 | No. 1 | Pages 18-20)

Abraham Szöke, William G Scott, János Hajdu Full-length article

18-20
The ‘antiporter module’ of respiratory chain Complex I includes the MrpC/NuoK subunit – a revision of the modular evolution scheme

14 August 2003 (Vol. 549 | No. 1 | Pages 7-13)

Cecilie Mathiesen, Cecilia Hägerhäll Full-length article

7-13
Are syn-ligated (bacterio)chlorophyll dimers energetic traps in light-harvesting systems?

19 June 2003 (Vol. 545 | No. 2 | Pages 97-102)

Teodor Silviu Balaban Full-length article

97-102
Adiponectin represents an independent cardiovascular risk factor predicting serum HDL-cholesterol levels in type 2 diabetes

19 June 2003 (Vol. 545 | No. 2 | Pages 103-104)

B Zietz, H Herfarth, G Paul, A Ehling, U Müller-Ladner, J Schölmerich, A Schäffler et al. Full-length article

103-104
Is a Q-cycle-like mechanism operative in dihaemic succinate:quinone and quinol:fumarate oxidoreductases?

22 May 2003 (Vol. 543 | No. 1 | Pages 1-4)

Manuela M. Pereira, Miguel Teixeira Full-length article

1-4
Oxidative stress in cell culture: an under-appreciated problem?

10 April 2003 (Vol. 540 | No. 1 | Pages 3-6)

Barry Halliwell Full-length article

3-6
A novel strategy to design binding molecules harnessing the modular nature of repeat proteins

27 March 2003 (Vol. 539 | No. 1 | Pages 2-6)

Patrik Forrer, Michael T. Stumpp, H.Kaspar Binz, Andreas Plückthun Full-length article

2-6
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