| | FEBS Letters Molecular Medicine
Virtual Special Issue FEBS Letters is proud to launch a new series of Virtual Special Issues which will highlight a collection of outstanding articles recently published in the journal, focusing on a selection of topics that we hope will be of general interest to our readers. The first of the series is a Virtual Special Issue on Molecular Medicine. The topic is deliberately broad, as we believe that this diversity is the strength of our journal, and will be appreciated by scientists from all fields. Molecular Medicine is a discipline in which modern biochemical research approaches are applied to understand the molecular mechanisms at the base of disease. Every scientific publication in the field of Molecular Medicine is a tiny, but indispensable, piece of the puzzle that must be completed in order to cure diseases. Here, we are presenting articles on pathologies ranging from Alzheimer's disease to cystic fibrosis, and have grouped them according to the major organs of the human body that they affect. In this issue you can find out how Wnt signalling can promote hepatic fibrosis by enhancing hepatic stellate cell activation and survival, or how an optineurin mutant can cause a familial form of glaucoma by over-interacting with TBK1. Are you aware that urine is a possible source of prion transmission? Do you know how activated macrophages can induce proteinuria in glomerular diseases? Find these and many other interesting articles in the FEBS Letters Molecular Medicine Virtual Special Issue. We wish you a pleasant and fruitful read!
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| Table of Contents
I. Alzheimer's and brain related diseases
II. Heart related diseases
III. Kidney related diseases
IV. Diabetes and Metabolism
V. Liver related diseases
VI. Pathologies of the eye
VII. Diseases of the connective tissue
VIII. Cystic Fibrosis
IX. Metabolic Detection |
I. Alzheimer's and brain related diseases
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The role of glycogen synthase kinase 3 in the early stages of Alzheimers’ disease
, 24 October 2008
Félix Hernández, Jesús Avila
FEBS Letters
26 November 2008 (Vol. 582, Issue 28, Pages 3848-3854)
Abstract
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Full Text on ScienceDirect
Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease
, 03 January 2008
Ying Liu, Fei Liu, Khalid Iqbal, Inge Grundke-Iqbal, Cheng-Xin Gong
FEBS Letters
23 January 2008 (Vol. 582, Issue 2, Pages 359-364)
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Full Text on ScienceDirect
The correlation between neurotoxicity, aggregative ability and secondary structure studied by sequence truncated Aβ peptides
, 20 February 2007
M.Q. Liao, Y.J. Tzeng, Lea Y.X. Chang, H.B. Huang, T.H. Lin, C.L. Chyan, Y.C. Chen
FEBS Letters
20 March 2007 (Vol. 581, Issue 6, Pages 1161-1165)
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Full Text on ScienceDirect
Critical role of PTEN in the coupling between PI3K/Akt and JNK1/2 signaling in ischemic brain injury
, 15 January 2007
Quan-Guang Zhang, Dong-Na Wu, Dong Han, Guang-Yi Zhang
FEBS Letters
6 February 2007 (Vol. 581, Issue 3, Pages 495-505)
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Full Text on ScienceDirect
RAGE signaling contributes to neuroinflammation in infantile neuronal ceroid lipofuscinosis
, 20 October 2008
Arjun Saha, Sung-Jo Kim, Zhongjian Zhang, Yi-Ching Lee, Chinmoy Sarkar, Pei-Chih Tsai, Anil B. Mukherjee
FEBS Letters
12 November 2008 (Vol. 582, Issue 27, Pages 3823-3831)
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Full Text on ScienceDirect
| II. Heart related diseases |
CD36 is a receptor for oxidized high density lipoprotein: Implications for the development of atherosclerosis
, 01 March 2007
Rick F. Thorne, Nizar M. Mhaidat, Kylie J. Ralston, Gordon F. Burns
FEBS Letters
20 March 2007 (Vol. 581, Issue 6, Pages 1227-1232)
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Full Text on ScienceDirect
Downregulation of angiotensin converting enzyme II is associated with pacing-induced sustained atrial fibrillation
, 17 January 2007
Chun-Hsu Pan, Jiunn-Lee Lin, Ling-Ping Lai, Chien-Lung Chen, Shoei K. Stephen Huang, Chih-Sheng Lin
FEBS Letters
6 February 2007 (Vol. 581, Issue 3, Pages 526-534)
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Full Text on ScienceDirect
Activation of peroxisome proliferator-activated receptor-α prevents glycogen synthase 3β phosphorylation and inhibits cardiac hypertrophy
, 19 June 2007
Ruifang Li, Wenhua Zheng, Rongbiao Pi, Jie Gao, Huijie Zhang, Ping Wang, Kang Le, Peiqing Liu
FEBS Letters
10 July 2007 (Vol. 581, Issue 17, Pages 3311-3316)
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Full Text on ScienceDirect
Endogenous microRNAs induced by heat-shock reduce myocardial infarction following ischemia–reperfusion in mice
, 26 November 2008
Chang Yin, Xiaoyin Wang, Rakesh C. Kukreja
FEBS Letters
24 December 2008 (Vol. 582, Issue 30, Pages 4137-4142)
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Full Text on ScienceDirect
Involvement of Sema4A in the progression of experimental autoimmune myocarditis
, 03 November 2008
Nobuhiko Makino, Toshihiko Toyofuku, Noriko Takegahara, Hyota Takamatsu, Tatsusada Okuno, Yukinobu Nakagawa, Sujin Kang, Satoshi Nojima, Masatsugu Hori, Hitoshi Kikutani, Atsushi Kumanogoh
FEBS Letters
26 November 2008 (Vol. 582, Issue 28, Pages 3935-3940)
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Full Text on ScienceDirect
| III. Kidney related diseases |
Transcriptional suppression of nephrin in podocytes by macrophages: Roles of inflammatory cytokines and involvement of the PI3K/Akt pathway
, 12 January 2007
Yosuke Takano, Kozue Yamauchi, Kunihiro Hayakawa, Nobuhiko Hiramatsu, Ayumi Kasai, Maro Okamura, Makiko Yokouchi, Akihiro Shitamura, Jian Yao, Masanori Kitamura
FEBS Letters
6 February 2007 (Vol. 581, Issue 3, Pages 421-426)
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Full Text on ScienceDirect
Uteroglobin interacts with the heparin-binding site of fibronectin and prevents fibronectin–IgA complex formation found in IgA-nephropathy
, 01 February 2008
Bhabadeb Chowdhury, Zhongjian Zhang, Anil B. Mukherjee
FEBS Letters
5 March 2008 (Vol. 582, Issue 5, Pages 611-615)
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Full Text on ScienceDirect
| IV. Diabetes and Metabolism |
Intermittent fasting prevents the progression of type I diabetic nephropathy in rats and changes the expression of Sir2 and p53
, 13 February 2007
Kulbhushan Tikoo, Durga Nand Tripathi, Dhiraj G. Kabra, Vikram Sharma, Anil Bhanudas Gaikwad
FEBS Letters
6 March 2007 (Vol. 581, Issue 5, Pages 1071-1078)
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Full Text on ScienceDirect
l-Arginine prevents metabolic effects of high glucose in diabetic mice
, 27 June 2008
Matthew B. West, Kota V. Ramana, Karin Kaiserova, Satish K. Srivastava, Aruni Bhatnagar
FEBS Letters
23 July 2008 (Vol. 582, Issue 17, Pages 2609-2614)
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Full Text on ScienceDirect
Negative regulation of adiponectin receptor 1 promoter by insulin via a repressive nuclear inhibitory protein element
, 10 September 2008
Xiaolan Sun, Jing He, Chenqian Mao, Ruijun Han, Zhenzhen Wang, Yong Liu, Yan Chen
FEBS Letters
15 October 2008 (Vol. 582, Issue 23, Pages 3401-3407)
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Full Text on ScienceDirect
| V. Liver related diseases |
PAI-1 deficiency reduces liver fibrosis after bile duct ligation in mice through activation of tPA
, 30 May 2007
Hongtao Wang, Yan Zhang, Robert O. Heuckeroth
FEBS Letters
26 June 2007 (Vol. 581, Issue 16, Pages 3098-3104)
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Full Text on ScienceDirect
Wnt signaling enhances the activation and survival of human hepatic stellate cells
, 30 May 2007
Sun Jung Myung, Jung-Hwan Yoon, Geum-Youn Gwak, Won Kim, Jeong-Hoon Lee, Kang Mo Kim, Chan Soo Shin, Ja June Jang, Sung-Hee Lee, Soo-Mi Lee, Hyo-Suk Lee
FEBS Letters
26 June 2007 (Vol. 581, Issue 16, Pages 2954-2958)
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Full Text on ScienceDirect
Hepatic stellate cell damage may lead to decreased plasma ADAMTS13 activity in rats
, 22 March 2007
Yukio Kume, Hitoshi Ikeda, Morihiro Inoue, Kazuaki Tejima, Tomoaki Tomiya, Takako Nishikawa, Naoko Watanabe, Tatsuya Ichikawa, Makoto Kaneko, Shigeo Okubo, Hiromitsu Yokota, Masao Omata, Kenji Fujiwara, Yutaka Yatomi
FEBS Letters
17 April 2007 (Vol. 581, Issue 8, Pages 1631-1634)
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Full Text on ScienceDirect
| VI. Pathologies of the eye |
A Stargardt disease-3 mutation in the mouse Elovl4 gene causes retinal deficiency of C32–C36 acyl phosphatidylcholines
, 05 November 2007
Anne McMahon, Shelley N. Jackson, Amina S. Woods, Wojciech Kedzierski
FEBS Letters
27 November 2007 (Vol. 581, Issue 28, Pages 5459-5463)
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Full Text on ScienceDirect
Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma
, 26 February 2008
Simon Morton, Luke Hesson, Mark Peggie, Philip Cohen
FEBS Letters
19 March 2008 (Vol. 582, Issue 6, Pages 997-1002)
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Full Text on ScienceDirect
| VII. Diseases of the connective tissue |
Osteoporotic bone formation in mice lacking tob2; involvement of Tob2 in RANK ligand expression and osteoclasts differentiation
, 19 March 2008
Rieko Ajima, Toru Akiyama, Michihiko Usui, Mitsuhiro Yoneda, Yutaka Yoshida, Takahisa Nakamura, Osamu Minowa, Masaki Noda, Sakae Tanaka, Tetsuo Noda, Tadashi Yamamoto
FEBS Letters
16 April 2008 (Vol. 582, Issue 9, Pages 1313-1318)
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Full Text on ScienceDirect
Pathogenic mitochondrial DNA-induced respiration defects in hematopoietic cells result in anemia by suppressing erythroid differentiation
, 11 April 2007
Shin-Ichi Inoue, Mutsumi Yokota, Kazuto Nakada, Hiroyuki Miyoshi, Jun-Ichi Hayashi
FEBS Letters
1 May 2007 (Vol. 581, Issue 9, Pages 1910-1916)
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Full Text on ScienceDirect
| VIII. Cystic Fibrosis |
The lactoperoxidase system links anion transport to host defense in cystic fibrosis
, 19 December 2006
Gregory E. Conner, Corinne Wijkstrom-Frei, Scott H. Randell, Vania E. Fernandez, Matthias Salathe
FEBS Letters
23 January 2007 (Vol. 581, Issue 2, Pages 271-278)
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Full Text on ScienceDirect
| IX. Metabolic Detection |
Circulating (cell-free) nucleic acids – A promising, non-invasive tool for early detection of several human diseases
, 01 February 2007
Vishnu Swarup, M.R. Rajeswari
FEBS Letters
6 March 2007 (Vol. 581, Issue 5, Pages 795-799)
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Full Text on ScienceDirect
Detection of infectious prions in urine
, 12 August 2008
Dennisse Gonzalez-Romero, Marcelo A. Barria, Patricia Leon, Rodrigo Morales, Claudio Soto
FEBS Letters
22 September 2008 (Vol. 582, Issue 21, Pages 3161-3166)
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Full Text on ScienceDirect
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