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Article Title |
Author(s) |
Type (Status) |
Available Online |
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Activation of spleen tyrosine kinase is required for TNF-α-induced endothelin-1 upregulation in human aortic endothelial cells
DOI: 10.1016/j.febslet.2012.01.055
Highlights: ► TNF-α-induced ROS activates Syk and PI3K. ► These are required to activate AP-1 and subsequent ET-1. ► ET-1 is implicated in the pathogenesis of atherosclerosis. ► Syk could be a possibl...
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Yoon Ji Kim,
Tai Yeon Koo,
Won Seok Yang,
Nam Jeong Han,
Jin Uk Jeong,
Sang Koo Lee,
Su-Kil Park
et al.
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Short communication
(In Press Accepted Manuscript)
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06 February 2012 |
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Asp563 of the horizontal helix of subunit NuoL is involved in proton translocation by the respiratory complex I
DOI: 10.1016/j.febslet.2012.01.056
Highlights: ► The respiratory complex I contains an unusual, horizontal’ helix on subunit NuoL. ► We mutated residues of the helix to investigate their role in proton translocation. ► The variants D56...
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Stefan Steimle,
Max Willistein,
Patricia Hegger,
Marco Janoschke,
Heiko Erhardt,
Thorsten Friedrich
et al.
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Short communication
(In Press Accepted Manuscript)
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06 February 2012 |
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Two sides of the story? Smad4 loss in pancreatic cancer versus head-and-neck cancer
DOI: 10.1016/j.febslet.2012.01.054
Abstract: TGFβ signaling Smads (Smad2, 3, and 4) were suspected tumor suppressors soon after their discovery. Nearly two decades of research confirmed this role and revealed other divergent and cancer...
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Stephen P. Malkoski,
Xiao-Jing Wang
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Review article
(In Press Accepted Manuscript)
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06 February 2012 |
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Insights into differential modulation of receptor function by hinge region using novel agonistic lutropin receptor and inverse agonistic thyrotropin receptor antibodies
DOI: 10.1016/j.febslet.2012.01.052
Highlights: ► First report of novel agonistic and antagonistic scFvs against LHR Hinge region. ► Discontinuous epitope of agonistic scFv comprises regions in both Cb-2 and Cb-3. ► Development of inver...
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Ritankar Majumdar,
Reema Railkar,
Rajan R Dighe
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Short communication
(In Press Accepted Manuscript)
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03 February 2012 |
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Construction of synthetic regulatory networks in yeast
DOI: 10.1016/j.febslet.2012.01.053
Abstract: Yeast species such as Saccharomyces cerevisiae have been exploited by humans for millennia and so it is therefore unsurprising that they are attractive cells to re-engineer for industrial us...
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Benjamin A. Blount,
Tim Weenink,
Tom Ellis
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Review article
(In Press Accepted Manuscript)
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03 February 2012 |
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Increased miR-222 in H. pylori-associated gastric cancer correlated with tumor progression by promoting cancer cell proliferation and targeting RECK
DOI: 10.1016/j.febslet.2012.01.025
Highlights: ► miR-222 is up-regulated both by H. pylori infection and in gastric cancer. ► Over-expression of miR-222 promotes cell proliferation and colony formation. ► RECK is a novel target of miR-...
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Na Li,
Bin Tang,
En-Dong Zhu,
Bo-sheng Li,
Yuan Zhuang,
Shu Yu,
Dong-shui Lu,
Quan-Ming Zou,
Bin Xiao,
Xu-Hu Mao
et al.
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Short communication
(In Press Uncorrected Proof)
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03 February 2012 |
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ATX and LPA receptor 3 are coordinately up-regulated in lipopolysaccharide-stimulated THP-1 cells through PKR and SPK1-mediated pathways
DOI: 10.1016/j.febslet.2012.01.044
Highlights: ► ATX and LPA3 are coordinately up-regulated by LPS in human monocytic THP-1 cells. ► PKR-mediated JNK1 and p38 MAPK activation is required for ATX and LPA3 induction. ► SPK1-mediated PI3K...
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Song Li,
Chaoyang Xiong,
Junjie Zhang
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Short communication
(In Press Uncorrected Proof)
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03 February 2012 |
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Pro42 and Val45 of staphylokinase modulate intermolecular interactions of His43–Tyr44 pair and specificity of staphylokinase–plasmin activator complex
DOI: 10.1016/j.febslet.2012.01.046
Highlights: ► Mutations at Pro42 and Val45 of SAK abrogate its Pg activation property. ► Pro42 and Val45 modulate contacts of His43–Tyr44 pair of SAK with Trp215 of plasmim. ► His43 is vulnerable than...
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Satish Singh,
F.N.U. Ashish,
Kanak L. Dikshit
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Short communication
(In Press Uncorrected Proof)
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03 February 2012 |
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Adaptive diversity of innate immune receptor family short pentraxins in Murinae
DOI: 10.1016/j.febslet.2012.01.048
Highlights: ► The evolutionary patterns of short pentraxins among rat, mouse, and eight other Murinae species and within five species were analyzed. ► Adaptive selection leads to rapid diversification...
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Yan Li,
Judith H. Robins,
Jianping Ye,
Zhiyong Huang,
Qiang Wen,
Guojie Zhang
et al.
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Short communication
(In Press Uncorrected Proof)
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01 February 2012 |
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Metabolic differences underlying two distinct rat urinary phenotypes, a putative role for gut microbial metabolism of phenylalanine and a possible connection to autism
DOI: 10.1016/j.febslet.2012.01.049
Highlights: ► This article explores the origin of two distinct rat urinary compositional phenotypes. ► An hypothesis is presented that involves gut microbial metabolism of phenylalanine. ► Specific me...
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T. Andrew Clayton
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Short communication
(In Press Uncorrected Proof)
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01 February 2012 |
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MicroRNA-203 leads to G1 phase cell cycle arrest in laryngeal carcinoma cells by directly targeting survivin
DOI: 10.1016/j.febslet.2012.01.050
Highlights: ► Overexpression of miR-203 inhibits laryngeal cancer cell proliferation. ► Survivin is a direct target of miR-203 in laryngeal cancer cells. ► Survivin plays a critical role in miR-203-in...
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Ka Bian,
Jing Fan,
Xiang Zhang,
Xin-Wei Yang,
Hua-Yu Zhu,
Lei Wang,
Jian-Yong Sun,
Yan-Ling Meng,
Peng-Cheng Cui,
Shi-Yin Cheng,
Jian Zhang,
Jing Zhao,
An-Gang Yang,
Rui Zhang
et al.
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Short communication
(In Press Uncorrected Proof)
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01 February 2012 |
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Cripto/GRP78 modulation of the TGF-β pathway in development and oncogenesis
DOI: 10.1016/j.febslet.2012.01.051
Abstract: Cripto is a small, GPI-anchored signaling protein that regulates cellular survival, proliferation, differentiation and migration during normal developmental processes and tumorigenesis. Crip...
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Peter C. Gray,
Wylie Vale
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Review article
(In Press Uncorrected Proof)
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01 February 2012 |
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Mapping key interactions in the dimerization process of HBHA from Mycobacterium tuberculosis, insights into bacterial agglutination
DOI: 10.1016/j.febslet.2012.01.047
Abstract: HBHA is a cell-surface protein implicated in the dissemination of Mycobacterium tuberculosis from the site of primary infection. Its N-terminal coiled-coil region is also involved in bacteri...
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Carla Esposito,
Marco Cantisani,
Gabriella D’Auria,
Lucia Falcigno,
Emilia Pedone,
Stefania Galdiero,
Rita Berisio
et al.
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Short communication
(In Press Accepted Manuscript)
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31 January 2012 |
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Kaiso uses all three zinc fingers and adjacent sequence motifs for high affinity binding to sequence-specific and methyl-CpG DNA targets
DOI: 10.1016/j.febslet.2012.01.045
Highlights: ► We have identified minimal Kaiso constructs for high-affinity DNA binding. ► All three Kaiso zinc fingers are required for binding. ► Extension of the sequence at the N-terminus increase...
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Bethany A. Buck-Koehntop,
Maria A. Martinez-Yamout,
H. Jane Dyson,
Peter E. Wright
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Short communication
(In Press Uncorrected Proof)
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31 January 2012 |
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MIG-13 controls anteroposterior cell migration by interacting with UNC-71/ADM-1 and SRC-1 in Caenorhabditis elegans
DOI: 10.1016/j.febslet.2012.01.031
Highlights: ► MIG-13 is crucial for anterior neural cell migration in Caenorhabditis elegans. ► A mutation in the unc-71 gene rescues the migration defects in mig-13 mutants. ► The unc-71 mutation als...
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Hitomi Masuda,
Kuniaki Nakamura,
Nozomu Takata,
Bunsho Itoh,
Takashi Hirose,
Hiroki Moribe,
Eisuke Mekada,
Masato Okada
et al.
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Short communication
(In Press Accepted Manuscript)
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30 January 2012 |
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A change in the sensitivity of elongation factor G to oxidation protects photosystem II from photoinhibition in Synechocystis sp. PCC 6803
DOI: 10.1016/j.febslet.2012.01.042
Highlights: ► We replace an ROS-sensitive Cys residue in elongation factor G (EF-G) by Ser. ► Expression of mutated EF-G in a cyanobacterium protects PSII from photoinhibition. ► The protection agains...
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Kayoko Ejima,
Tomoko Kawaharada,
Shuhei Inoue,
Kouji Kojima,
Yoshitaka Nishiyama
et al.
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Short communication
(In Press Uncorrected Proof)
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30 January 2012 |
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OIT3 deficiency impairs uric acid reabsorption in renal tubule
DOI: 10.1016/j.febslet.2012.01.038
Highlights: ► We create an OIT3 null mouse model. ► Lower serum uric acid level in OIT3 null mice could be due to increase of uric acid excretion. ► Excretion of THP in urine increases while renal THP...
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Bing Yan,
Zhuang-Zhuang Zhang,
Li-Yu Huang,
Hai-Lian Shen,
Ze-Guang Han
et al.
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Short communication
(In Press Uncorrected Proof)
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30 January 2012 |
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Use of Kikume green–red fusions to study the influence of pharmacological chaperones on trafficking of G protein-coupled receptors
DOI: 10.1016/j.febslet.2012.01.043
Highlights: ► We constructed fusions of the vasopressin V2 receptor with the photoconvertible mKikGR protein. ► We show that mKikGR fusions can be used to study receptor trafficking. ► Using mKikGR fu...
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Ingrid Ridelis,
Antje Schmidt,
Anke Teichmann,
Jens Furkert,
Burkhard Wiesner,
Ralf Schülein
et al.
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Short communication
(In Press Uncorrected Proof)
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30 January 2012 |
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HBXIP upregulates CD46, CD55 and CD59 through ERK1/2/NF-κB signaling to protect breast cancer cells from complement attack
DOI: 10.1016/j.febslet.2012.01.039
Abstract: Hepatitis B X-interacting protein (HBXIP) is able to enhance migration of breast cancer cells. However, the role of HBXIP in regulation of complement-dependent cytotoxicity (CDC) in breast c...
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Wenjing Cui,
Yu Zhao,
Changliang Shan,
Guangyao Kong,
Nan Hu,
Yiwen Zhang,
Shuai Zhang,
Weiying Zhang,
Yingyi Zhang,
Xiaodong Zhang,
Lihong Ye
et al.
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Short communication
(In Press Uncorrected Proof)
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30 January 2012 |
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Oligomeric interactions of TGF-β and BMP receptors
DOI: 10.1016/j.febslet.2012.01.040
Abstract: Transforming growth factor-β (TGF-β) and bone morphogenetic protein (BMP) cytokines participate in a multiplicity of ways in the regulation of numerous physiological and pathological process...
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Marcelo Ehrlich,
Orit Gutman,
Petra Knaus,
Yoav I. Henis
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Review article
(In Press Uncorrected Proof)
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30 January 2012 |
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Selenomodification of tRNA in archaea requires a bipartite rhodanese enzyme
DOI: 10.1016/j.febslet.2012.01.024
Highlights: ► A bipartite archaeal tRNA 2-selenouridine synthase (SelU) was identified in silico. ► Both proteins are required to catalyze tRNA selenation in vivo and in vitro. ► SelU presumably was p...
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Dan Su,
Temitope T. Ojo,
Dieter Söll,
Michael J. Hohn
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Short communication
(In Press Uncorrected Proof)
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30 January 2012 |
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Smad-mediated regulation of microRNA biosynthesis
DOI: 10.1016/j.febslet.2012.01.041
Abstract: microRNAs (miRNAs) are small non-coding RNAs conserved in metazoans. Depletion of miRNAs results in embryonic lethality, suggesting they are essential for embryogenesis. Similarly, pathways ...
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Matthew T. Blahna,
Akiko Hata
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Review article
(In Press Uncorrected Proof)
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30 January 2012 |
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Overexpression of lalA, a paralog of labA, is capable of affecting both circadian gene expression and cell growth in the cyanobacterium Synechococcus elongatus PCC 7942
DOI: 10.1016/j.febslet.2012.01.035
Highlights: ► lalA is a paralog of the cyanobacterial clock-related gene labA. ► lalA overexpression reduced amplitude of circadian kaiBC expression. ► lalA overexpression advanced phases of circadian...
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Yasuhito Taniguchi,
Tomoe Nishikawa,
Takao Kondo,
Tokitaka Oyama
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Short communication
(In Press Accepted Manuscript)
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27 January 2012 |
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Cyclin-dependent kinase 4 is a novel target in micoRNA-195-mediated cell cycle arrest in bladder cancer cells
DOI: 10.1016/j.febslet.2012.01.027
Highlights: ► miR-195 is down-regulated in bladder cancer tissue samples. ► miR-195 inhibits bladder cancer cell T24 growth both in vitro and in vivo. ► miR-195 could induce T24 cell cycle arrest by s...
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Yiwei Lin,
Jian Wu,
Hong Chen,
Yeqing Mao,
Yunfu Liu,
Qiqi Mao,
Kai Yang,
Xiangyi Zheng,
Liping Xie
et al.
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Short communication
(In Press Corrected Proof)
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27 January 2012 |
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LY294002 inhibits TLR3/4-mediated IFN-β production via inhibition of IRF3 activation with a PI3K-independent mechanism
DOI: 10.1016/j.febslet.2012.01.016
Highlights: ► LY294002 and wortmannin have opposite functions on LPS- and poly(I:C)-induced IFN-β production. ► LY294002 inhibits LPS- and poly(I:C)-induced IFN-β transcription and secretion in a PI3K...
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Wei Zhao,
Jianni Qi,
Lijuan Wang,
Meng Zhang,
Peng Wang,
Chengjiang Gao
et al.
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Short communication
(In Press Accepted Manuscript)
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27 January 2012 |
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Phosphate homeostasis in the yeast Saccharomyces cerevisiae, the key role of the SPX domain-containing proteins
DOI: 10.1016/j.febslet.2012.01.036
Abstract: In the yeast Saccharomyces cerevisiae, a working model for nutrient homeostasis in eukaryotes, inorganic phosphate (Pi) homeostasis is regulated by the PHO pathway, a set of phosphate starva...
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David Secco,
Chuang Wang,
Huixia Shou,
James Whelan
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Review article
(In Press Corrected Proof)
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27 January 2012 |
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Novel assay with fluorescence-labeled PrP peptides for differentiating L-type atypical and classical BSEs, and scrapie
DOI: 10.1016/j.febslet.2012.01.012
Abstract Characteristic differences of prions may account for the conformational diversity of the pathogenic isoform of prion protein (PrPSc). Here, we applied a protein detection procedure by using f...
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Kazuo Kasai,
Akiyoshi Hitara,
Takafumi Ohyama,
Kiyoshi Nokihara,
Takashi Yokoyama,
Shirou Mohri
et al.
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Short communication
(In Press Accepted Manuscript)
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27 January 2012 |
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Delivery of Bordetella pertussis adenylate cyclase toxin to target cells via outer membrane vesicles
DOI: 10.1016/j.febslet.2012.01.032
Highlights: ► Bordetella pertussis produce outer membrane vesicles (OMV) that contain biologically active adenylate cyclase toxin (ACT). ► OMV–ACT enter host cells by a mechanism distinct from soluble...
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Gina M. Donato,
Cynthia S. Goldsmith,
Christopher D. Paddock,
Joshua C. Eby,
Mary C. Gray,
Erik L. Hewlett
et al.
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Short communication
(In Press Uncorrected Proof)
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27 January 2012 |
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Crystal structure of cce_0566 from Cyanothece 51142, a protein associated with nitrogen fixation in the DUF269 family
DOI: 10.1016/j.febslet.2012.01.037
Highlights: ► First structural characterization of a protein from the DUF269 family. ► Dali search indicates protein fold is unique in current protein space. ► Homodimer with each unit containing 8 α-...
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Garry W. Buchko,
Howard Robinson
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Short communication
(In Press Uncorrected Proof)
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27 January 2012 |
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RUVBL2 is a novel repressor of ARF transcription
DOI: 10.1016/j.febslet.2012.01.026
Highlights: ► RUVBL2 transcriptionally represses ARF expression. ► RUVBL2 binds to the distal region of ARF promoter. ► RUVBL2 down-regulates p53 in an ARF-dependent manner.Abstract: ARF is the second...
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Chongwei Xie,
Wenyu Wang,
Fan Yang,
Mian Wu,
Yide Mei
et al.
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Short communication
(In Press Uncorrected Proof)
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27 January 2012 |
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The β1 domain of protein G can replace the chorismate mutase domain of the T-protein
DOI: 10.1016/j.febslet.2012.01.033
Highlights: ► Gβ1 can replace AroQT in the T-protein. ► AroQT/TyrA specific-contact interface is not important to maintain a functional T-protein. ► Gβ1N-terminal β-hairpin residues are important to m...
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Joel Osuna,
Humberto Flores,
Gloria Saab-Rincón
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Short communication
(In Press Uncorrected Proof)
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27 January 2012 |
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Transcription-independent role of Bach1 in mitosis through a nuclear exporter Crm1-dependent mechanism
DOI: 10.1016/j.febslet.2012.01.028
Highlights: ► We revealed that Bach1 has a novel function beyond transcriptional regulation. ► Bach1 functions to maintain mitotic chromosome alignment. ► The exclusion of Bach1 from mitotic chromosom...
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Jie Li,
Takuma Shiraki,
Kazuhiko Igarashi
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Short communication
(In Press Corrected Proof)
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27 January 2012 |
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Cataract-linked γD-crystallin mutants have weak affinity to lens chaperones α-crystallins
DOI: 10.1016/j.febslet.2012.01.019
Highlights: ► How can destabilizing mutations of lens γ-crystallin cause cataract? ► Cataract-causing mutations stabilize an unfolding intermediate of γD-crystallin. ► Cataract-causing mutants of γD-c...
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Sanjay Mishra,
Richard A. Stein,
Hassane S. Mchaourab
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Short communication
(In Press Uncorrected Proof)
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27 January 2012 |
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N-Acetyl lysyl-tRNA synthetases evolved by a CcdB-based selection possess N-acetyl lysine specificity in vitro and in vivo
DOI: 10.1016/j.febslet.2012.01.029
Highlights: ► N-Acetyl lysyl-tRNA synthetases were evolved by a CcdB-based selection. ► N-Acetyl lysine specificity was validated by both in vitro and in vivo approaches. ► Kinetic properties of the e...
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Takuya Umehara,
Jihyo Kim,
Sangsik Lee,
Li-Tao Guo,
Dieter Söll,
Hee-Sung Park
et al.
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Short communication
(In Press Accepted Manuscript)
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27 January 2012 |
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Scythe cleavage during Fas (APO-1)-and staurosporine-mediated apoptosis
DOI: 10.1016/j.febslet.2012.01.034
Highlights: ► Cleavage of Scythe/BAT3 by caspase-3 correlates with its translocation to the cytosol. ► Cytosolic Scythe is required for phosphatidylserine exposure in Fas-triggered cells. ► Cleavage o...
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Giulio Preta,
Bengt Fadeel
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Short communication
(In Press Uncorrected Proof)
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27 January 2012 |
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Saccharomyces cerevisiae gene YMR291W/TDA1 mediates the in vivo phosphorylation of hexokinase isoenzyme 2 at serine-15
DOI: 10.1016/j.febslet.2012.01.030
Highlights: ► The monomer–homodimer equilibrium of Hxk2 is affected by serine-15 phosphorylation. ► High-resolution clear-native PAGE is appropriate for phosphohexokinase detection. ► Protein kinase s...
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Karina Kettner,
Udo Krause,
Sophie Mosler,
Claudia Bodenstein,
Thomas Kriegel,
Gerhard Rödel
et al.
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Short communication
(In Press Accepted Manuscript)
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27 January 2012 |
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MIZ1, an essential protein for root hydrotropism, is associated with the cytoplasmic face of the endoplasmic reticulum membrane in Arabidopsis root cells
DOI: 10.1016/j.febslet.2012.01.008
Highlights: ► MIZ1 is a previously uncharacterized protein encoded by a gene essential for root hydrotropism. ► GFP-tagged MIZ1 is associated with the endoplasmic reticulum membrane (ER) at the cytoso...
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Tomokazu Yamazaki,
Yutaka Miyazawa,
Akie Kobayashi,
Teppei Moriwaki,
Nobuharu Fujii,
Hideyuki Takahashi
et al.
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Short communication
(In Press Uncorrected Proof)
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25 January 2012 |
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Unusual NADPH conformation in the crystal structure of a cinnamyl alcohol dehydrogenase from Helicobacter pylori in complex with NADP(H) and substrate docking analysis
DOI: 10.1016/j.febslet.2012.01.020
Highlights: ► The binary structure of HpCAD complex NADP(H) is solved at 2.18Å. ► An unusual conformation of the 2′phosphate group of the NADPH, not seen in other CAD structures, was found. ► Docking ...
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Kyung Hye Seo,
Ningning Zhuang,
Cong Chen,
Jae-Young Song,
Hyung-Lyun Kang,
Kwang-Ho Rhee,
Kon Ho Lee
et al.
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Short communication
(In Press Corrected Proof)
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23 January 2012 |
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Ribosome-independent biosynthesis of biologically active peptides: Application of synthetic biology to generate structural diversity
DOI: 10.1016/j.febslet.2012.01.017
Abstract: Peptide natural products continue to play an important role in modern medicine as last-resort treatments of many life-threatening diseases, as they display many interesting biological activi...
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Tobias W. Giessen,
Mohamed A. Marahiel
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Review article
(In Press Corrected Proof)
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23 January 2012 |
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Mitochondrial ATP-sensitive potassium channel activity and hypoxic preconditioning are independent of an inwardly rectifying potassium channel subunit in Caenorhabditis elegans
DOI: 10.1016/j.febslet.2012.01.021
Highlights: ► A mitochondrial KATP channel (mKATP) is central to ischemic preconditioning (IPC). ► A Kir family member is thought to form the mKATP. ► C. elegans benefit from IPC and display mKATP act...
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Andrew P. Wojtovich,
Peter DiStefano,
Teresa Sherman,
Paul S. Brookes,
Keith Nehrke
et al.
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Short communication
(In Press Corrected Proof)
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23 January 2012 |
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Is the chromanol head group of vitamin E nature’s final truth on chain-breaking antioxidants?
DOI: 10.1016/j.febslet.2012.01.022
Highlights: ► Quantum chemical calculations indicate that even refined phenols like chromanol may be suboptimal antioxidants. ► Aromatic amine (NH) analogues of two chromanols, tocopherol and trolox, ...
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Maike J. Ohlow,
Matthias Granold,
Mathias Schreckenberger,
Bernd Moosmann
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Short communication
(In Press Uncorrected Proof)
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23 January 2012 |
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Dimerization, but not phosphothreonine binding, is conserved between the forkhead-associated domains of Drosophila MU2 and human MDC1
DOI: 10.1016/j.febslet.2012.01.023
Highlights: ► The crystal structure of the MU2 FHA domain reveals a dimer. ► The FHA dimer interface is different between MU2 and MDC1. ► The phosphothreonine-binding pocket of MU2 FHA is degenerate. ...
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Shukun Luo,
Keqiong Ye
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Short communication
(In Press Corrected Proof)
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23 January 2012 |
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Verification of the interdomain contact site in the inactive monomer, and the domain-swapped fold in the active dimer of Hsp33 in solution
DOI: 10.1016/j.febslet.2012.01.011
Highlights: ► We examine physiological relevance of the known crystal structures of Hsp33. ► Interdomain contact site in the inactive monomer is validated in solution. ► Domain-swapped fold of the act...
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Yoo-Sup Lee,
Kyoung-Seok Ryu,
Seo-Jin Kim,
Hyun-Suk Ko,
Dae-Won Sim,
Young Ho Jeon,
Eun-Hee Kim,
Wahn-Soo Choi,
Hyung-Sik Won
et al.
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Short communication
(In Press Corrected Proof)
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18 January 2012 |
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Single-particle tracking of immunoglobulin E receptors (FcεRI) in micron-sized clusters and receptor patches
DOI: 10.1016/j.febslet.2012.01.013
Highlights: ► Super-resolution single-particle tracking of immune receptors. ► FcεRI receptors maintain lateral mobility inside receptor clusters. ► FcεRI receptor immobilization is not required for s...
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Kathrin Spendier,
Keith A. Lidke,
Diane S. Lidke,
James L. Thomas
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Short communication
(In Press Corrected Proof)
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18 January 2012 |
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Phosphosite conservation in single domain orthologs versus paralogs: A way to combine differential regulation with redundant core functions
DOI: 10.1016/j.febslet.2012.01.018
Highlights: ► Isoform co-expression in various tissues necessitates differential regulation. ► Conserved point mutations in single domain paralogs with similar core functions. ► Data mining indicates ...
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Lynn Huyck,
Marleen Van Troys,
Christophe Ampe
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Short communication
(In Press Corrected Proof)
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18 January 2012 |
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Approaches to chemical synthetic biology
DOI: 10.1016/j.febslet.2012.01.014
Highlights: ► Introducing the notion of chemical synthetic biology. ► Highlight the use of lipid vesicles as cell models. ► The laboratory construction of synthetic minimal cell for basic and applied ...
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Cristiano Chiarabelli,
Pasquale Stano,
Fabrizio Anella,
Paolo Carrara,
Pier Luigi Luisi
et al.
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Review article
(In Press Corrected Proof)
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18 January 2012 |
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MiR-18a regulates expression of the pancreatic transcription factor Ptf1a in pancreatic progenitor and acinar cells
DOI: 10.1016/j.febslet.2012.01.015
Highlights: ► We explore the role of miR-18a in pancreatic progenitor and acinar cells. ► We find that miR-18a targets Ptf1a 3′UTR to decrease its protein and mRNA levels. ► MiR-18a regulates pancreat...
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Yankun Yang,
Lei Ding,
Yang An,
Zhen-wu Zhang,
Yanhe Lang,
Sheng Tai,
Fangqi Guo,
Chun-Bo Teng
et al.
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Short communication
(In Press Corrected Proof)
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18 January 2012 |
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Follistatin-related protein/follistatin-like 1 evokes an innate immune response via CD14 and toll-like receptor 4
DOI: 10.1016/j.febslet.2012.01.010
Highlights: ► This is the first report to clarify how FRP acts in immunity on a molecular level. ► FRP associates with CD14 on the cell surface and triggers TLR4 signaling. ► FRP is considered to be a...
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Kosaku Murakami,
Masao Tanaka,
Takashi Usui,
Daisuke Kawabata,
Aoi Shiomi,
Mikiko Iguchi-Hashimoto,
Masakazu Shimizu,
Naoichiro Yukawa,
Hajime Yoshifuji,
Takaki Nojima,
Koichiro Ohmura,
Takao Fujii,
Hisanori Umehara,
Tsuneyo Mimori
et al.
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Short communication
(In Press Corrected Proof)
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18 January 2012 |
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Human synaptotagmin-II is not a high affinity receptor for botulinum neurotoxin B and G: Increased therapeutic dosage and immunogenicity
DOI: 10.1016/j.febslet.2011.12.037
Highlights: ► Synaptotagmin-II of rat and mouse acts as neuronal high affinity receptor for BoNT/B and G. ► Mutation F54L converts rat synaptotagmin-II to a low affinity receptor of BoNT/B and G. ► F5...
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Jasmin Strotmeier,
Gesche Willjes,
Thomas Binz,
Andreas Rummel
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Short communication
(In Press Corrected Proof)
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16 January 2012 |
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MicroRNA-195-5p suppresses glucose uptake and proliferation of human bladder cancer T24 cells by regulating GLUT3 expression
DOI: 10.1016/j.febslet.2012.01.006
Highlights: ► miR-195-5p negatively regulates the expression of GLUT3 through GLUT3 3’UTR. ► miR-195-5p is the first identified microRNA that targets GLUT3. ► Over-expression of miR-195-5p decreases G...
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Xiang Fei,
Manlong Qi,
Bin Wu,
Yongsheng Song,
Yueping Wang,
Tingting Li
et al.
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Short communication
(In Press Corrected Proof)
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16 January 2012 |
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Crystal structures of the coil 2B fragment and the globular tail domain of human lamin B1
DOI: 10.1016/j.febslet.2012.01.007
Highlights: ► Crystal structures of the human lamin B1 coil 2B and tail domains are presented. ► These two domains in lamin B1 adopt conserved folds to those of lamin A/C. ► An intermolecular disulfid...
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Jianbin Ruan,
Chao Xu,
Chuanbing Bian,
Robert Lam,
Jia-Pey Wang,
Joanna Kania,
Jinrong Min,
Jianye Zang
et al.
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Short communication
(In Press Uncorrected Proof)
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16 January 2012 |
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Back-reactions, short-circuits, leaks and other energy wasteful reactions in biological electron transfer: Redox tuning to survive life in O2
DOI: 10.1016/j.febslet.2011.12.039
Abstract: The energy-converting redox enzymes perform productive reactions efficiently despite the involvement of high energy intermediates in their catalytic cycles. This is achieved by kinetic contr...
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A. William Rutherford,
Artur Osyczka,
Fabrice Rappaport
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Review article
(In Press Corrected Proof)
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16 January 2012 |
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Identification of essential sequences for cellular localization in the muscle-specific ubiquitin E3 ligase MAFbx/Atrogin 1
DOI: 10.1016/j.febslet.2011.12.031
Highlights: ► Sequences governing nucleo-cytoplasmic shuttling of MAFbx in muscle atrophy. ► A non-canonical nuclear export signal controls cytoplasmic localization of MAFbx. ► Increasing informations...
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Lagirand-Cantaloube Julie,
Batonnet-Pichon Sabrina,
Leibovitch Marie-Pierre,
Serge A. Leibovitch
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Short communication
(In Press Corrected Proof)
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12 January 2012 |
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PEDV ORF3 encodes an ion channel protein and regulates virus production
DOI: 10.1016/j.febslet.2012.01.005
Highlights: ► Computational modeling of PEDV OFR3 protein. ► Wild-type PEDV ORF3 protein functions as an ion channel and regulates virus production. ► The truncated protein encoded by an attenuated-ty...
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Kai Wang,
Wei Lu,
Jianfei Chen,
Shiqi Xie,
Hongyan Shi,
Haojen Hsu,
Wenjing Yu,
Ke Xu,
Chao Bian,
Wolfgang B. Fischer,
Wolfgang Schwarz,
Li Feng,
Bing Sun
et al.
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Short communication
(In Press Corrected Proof)
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12 January 2012 |
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SNPs of hemocyanin C-terminal fragment in shrimp Litopenaeus vannamei
DOI: 10.1016/j.febslet.2011.12.038
Highlights: ► We found for the first time that the C-terminus of hemocyanin possessed SNPs. ► It could be modulated by a specific environmental stress. ► Some specific SNP sites might be associated wi...
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Xianliang Zhao,
Lingling Guo,
Yueling Zhang,
Yao Liu,
Xiaoyu Zhang,
Jingsheng Lun,
Jiehui Chen,
Yuanyou Li
et al.
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Short communication
(In Press Corrected Proof)
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12 January 2012 |
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Hypoxia-induced SM22α in A549 cells activates the IGF1R/PI3K/Akt pathway, conferring cellular resistance against chemo- and radiation therapy
DOI: 10.1016/j.febslet.2011.12.036
Highlights: ► SM22α is induced in A549 non-small cell lung carcinoma cells by hypoxia. ► SM22α overexpression increased chemo- and radiation-resistance of A549 NSCLC cells. ► Hypoxia-mediated inductio...
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Tae Rim Kim,
Eun Wie Cho,
Sang Gi Paik,
In Gyu Kim
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Short communication
(In Press Corrected Proof)
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11 January 2012 |
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Identification and characterization of an LCAT-like Arabidopsis thaliana gene encoding a novel phospholipase A
DOI: 10.1016/j.febslet.2011.12.034
Abstract: A previously uncharacterized Arabidopsis lecithin:cholesterol acyltransferase (LCAT) family gene (At4g19860) was functionally expressed in yeast, where it was demonstrated to encode a novel ...
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Guanqun Chen,
Michael S. Greer,
Ida Lager,
Jenny Lindberg Yilmaz,
Elzbieta Mietkiewska,
Anders S. Carlsson,
Sten Stymne,
Randall J. Weselake
et al.
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Short communication
(In Press Corrected Proof)
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11 January 2012 |
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Yeast ribosomal protein S3 possesses a β-lyase activity on damaged DNA
DOI: 10.1016/j.febslet.2011.12.030
Highlights: ► Yeast Rps3p cleaves not only AP sites and pyrimidine dimers but also 8-oxo-G. ► Yeast Rps3p could cleave pyrimidine dimers without glycosylase activity. ► Asp154 and Lys200 are identifie...
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Ki Moon Seong,
Sang-Oun Jung,
Hag Dong Kim,
Hee Ju Kim,
You-Jin Jung,
Soo-Young Choi,
Joon Kim
et al.
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Short communication
(In Press Corrected Proof)
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11 January 2012 |
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Inflammatory changes in adipose tissue enhance expression of GPR84, a medium-chain fatty acid receptor: TNFα enhances GPR84 expression in adipocytes
DOI: 10.1016/j.febslet.2012.01.001
Highlights: ► GPR84 has been identified as a receptor for medium-chain fatty acids (MCFAs). ► GPR84 appears in white adipose tissue during the onset of obesity. ► TNFα from macrophages enhances GPR84 ...
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Hiroshi Nagasaki,
Takaaki Kondo,
Masahiro Fuchigami,
Hiroyuki Hashimoto,
Yoshihisa Sugimura,
Nobuaki Ozaki,
Hiroshi Arima,
Akira Ota,
Yutaka Oiso,
Yoji Hamada
et al.
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Short communication
(In Press Corrected Proof)
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11 January 2012 |
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Sorbitol dehydrogenase of Aspergillus niger, SdhA, is part of the oxido-reductive d-galactose pathway and essential for d-sorbitol catabolism
DOI: 10.1016/j.febslet.2012.01.004
Highlights: ► We identified the sorbitol dehydrogenase gene in Aspergillusniger. ► It is part of the oxido-reductive d-galactose pathway. ► It is upregulated on d-sorbitol, d-galactose and galactitol....
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Outi M. Koivistoinen,
Peter Richard,
Merja Penttilä,
Laura Ruohonen,
Dominik Mojzita
et al.
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Short communication
(In Press Corrected Proof)
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11 January 2012 |